In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids

Native pancreatic islets interact with neighboring cells by establishing three-dimensional (3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow effects are generally ignored in islet culture models, although cell perfusion is known to improve the cell microenvironment and to mimic in vivo physiology better than static culture systems. Here, we have developed functional islet spheroids using a microfluidic chip that mimics interstitial flow conditions with reduced shear cell damage. Dynamic culture, compared to static culture, enhanced islet health and maintenance of islet endothelial cells, reconstituting the main component of islet extracellular matrix within spheroids. Optimized flow condition allowed localization of secreted soluble factors near spheroids, facilitating diffusion-mediated paracrine interactions within islets, and enabled long-term maintenance of islet morphology and function for a month. The proposed model can aid islet preconditioning before transplantation and has potential applications as an in vitro model for diabetic drug testing. Diabetes mellitus (DM) is a prevalent and chronic metabolic disorder that affects app...

China Business gift sets, graduation gifts, sport gifts, office gifts, wedding gift, birthday gifts on Global Sources

We use cookies to give you the best possible experience on our website. For more details including how to change your cookie settings, please read our Cookie Policy. Path: All Categories >> Gifts & Premiums >> Stationery Supplies >> School & Office Stationery >> Office stationery sets – Update me on new products View latest products We’ve sent a confirmation e-mail to XXX@gmail.com. Click on the link in the e-mail to activate and start receiving free alerts when new products are posted! Take the next step in your sourcing journey with Global Sources. From now until December 31, 2019, for every US$100 worth of sample orders you make on GlobalSources.com, you’ll receive a US$20 Amazon.com Gift Card*, our way of helping you towards your next million-dollar product. Established in 2003, Sonier Pins Co. Ltd. We are running a family business, has 15 years’ OEM/ODM experience. Our factory covers 3,600 square meters and employs 68 workers, which can provide designing, molding and producing services for customers. We have 25 sales representatives, five engineer and three designers, who can handle your projects in a more professional and quicker way, ...

Best electric scooter deals for Black Friday: save up to £500 on adult electric scooters!

Looking for an electric scooter? Whether you’re planning on getting one to make your commute easier, or you fancy an exhilarating new toy for Christmas, you can currently pick up a fantastic deal on an electric scooter for Black Friday. Pure Scooters – one of the UK’s largest retailers of electric scooters – is offering some mega-discounts, knocking as much as £500 off some of its most popular models. The sale includes £100 off the Segway-Ninebot ES4 Electric Scooter, which is currently second in T3′s guide to the best electric scooters. We were super impressed with its combination of high-speed, low-weight, and long-range, and we’re sure you will be as well. There are also more affordable options from Segway-Ninebot on sale, such as the SE1 and SE2, which are selling for £298.99 and £398.99 respectively.  You can also save £100 on the massively popular Xiaomi M365, which brings the price down to just £298.99.  It’s worth noting that all scooters purchased from Pure come with a two-year manufacturer’s warranty, and are shipped from the UK so you won’t be left waiting weeks for delivery from China. Xiaomi M365 Electric Scooter | was £398....

Fabrication shop tours highlight the latest in digital technology The FABRICATOR STAMPING Journal The Welder The Tube and Pipe Journal The FABRICATOR en Español The Additive Report The FABRICATOR The Welder The Tube and Pipe Journal STAMPING Journal The Additive Report The FABRICATOR en Español

Specializing in tube-cutting laser machines since it was founded, Tube Tech Machinery makes machines that cut ODs from 0.5 to 32 in. The versatility of a laser machine with a fully articulating head makes quick (and precise) work of coping for complex joints such as this one. Finding the right pace for a manufacturing process is anything but easy. In the old days, when manufacturing was characterized by batch production and long part runs, the right pace was the fastest possible pace. A typical machine setup took a substantial amount of time, so profitability hinged on amortizing that setup time over the longest production run possible. Manufacturers ran the equipment as fast as possible for long periods of time to make vast batches of components. Warehouses were full of inventory. Every accountant’s nightmare, work-in-progress (WIP), ruled manufacturing. Fast-forward to the current era, one characterized by CNC programming and quick-change tooling. Setups are almost effortless, requiring much less time than in the past. During the interim, the digital transformation led to computer systems and software capable of doing much more than in the past, helping enterprise resource pla...

RC addiction lets you have a real-time thrilling experience with some powerful cars on the track.

RC addiction lets you have a real-time thrilling experience with some powerful cars on the track. It’s obvious why RC cars are so popular among the car lovers and people who seek pleasure in driving and drifting cars. Not only the children, RC cars are also popular among the young people who love cars. Drifting or Drift Racing is a very famous hobby for both the professional drivers and the fans they love driving or watching cars racing. If you are new to this hobby or have been thinking to get a RC car or you want to learn the thrilling driving experience of drift racing, you have come to the right place. The RC Drifting started many years ago from Japan, where people used to race their home-built RC cars, which then flourished in to a proper DRIFTING COMPETITION that takes place every year around the world. Many of the toy manufacturing companies saw the demand for RC Cars and started producing RC Drift cars, and now we can not only watch the drift racing on our TVs but also enjoy driving and drifting it personally. Among all the remote controlled toys including Quad-copters, Boats, Helicopters and Airplanes, RC Cars are the toughest and most liked remote controlled toys in t...

Asia PP capacity expansion poses challenges to Mideast suppliers

SINGAPORE (ICIS)–Significant polypropylene (PP) capacity expansion in Asia could squeeze the market share of Middle East suppliers in the region. In the coming three years, 80% of the global PP expansion is concentrated in Asia, where capacity is expected to increase over the period by more than 8m tonnes/year, more than two-thirds of which will be in China. On the other hand, capacity expansion in the Middle East is limited, with only Orpic’s 300,000 tonne/year unit in Oman expected to come on stream in the first quarter of 2020, and Borouge’s 450,000 tonne/year unit in the UAE due to start up around 2022. The Middle East has been the largest PP net exporting region in the world, with more than 40% of shipments flowing into Asia, according to the ICIS Supply and Demand database. For China, which imports about 5m tonnes of PP on an annual basis, Middle East cargoes accounted for about a fifth of the total since 2017, the data showed. Going forward, Middle East-origin cargoes may flow more into North America and Europe, where demand is expected to increase amid scarce local capacity expansion. Despite the expected shift in trade flows stemming from capacity expansions in th...

When it comes to machining, particularly in metal, rigidity is everything. [Tailortech] had a homebuilt CNC

When it comes to machining, particularly in metal, rigidity is everything. [Tailortech] had a homebuilt CNC machine with a spindle held in place by a plastic bracket. This just wasn’t up to the job, so the decision was made to cast a replacement. [Tailortech] decided to use the lost PLA process – a popular choice amongst the maker crowd. The spindle holder was first sketched out, then modeled in Fusion 3D 360. This was then printed in PLA slightly oversized to account for shrinkage in the casting process. The PLA part was then used to make a plaster mold. [Tailortech] explains the process, and how to avoid common pitfalls that can lead to problems. It’s important to properly heat the mold once the plaster has set to remove moisture, but care must be taken to avoid cracking or wall calcination. It’s then necessary to slowly heat the mold to even higher temperatures to melt out the PLA prior to casting. With the mold completed, it can be filled with molten aluminium to produce the final part. When it’s cooled off, it’s then machined to final tolerances and installed on the machine. Lost PLA casting is a versatile process, and goes to show that not everything has to be CNC machined...

Smart Lock Market 2019-2023 | Evolving Opportunities with Allegion Plc and Honeywell International Inc.| Technavio | Business

Smart Lock Market 2019-2023 | Evolving Opportunities with Allegion Plc and Honeywell International Inc.| Technavio Smart Lock Market 2019-2023 | Evolving Opportunities with Allegion Plc and Honeywell International Inc.| Technavio The global smart lock market size is poised to grow by USD 8.62 billion during 2019-2023, registering a CAGR of close to 15% during the forecast period. However, the market is anticipated to witness a decelerating year-over-year growth during the forecast period. Request Free Sample Pages This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20191111005528/en/ Technavio has announced its latest market research report titled global smart lock market 2019-2023. (Graphic: Business Wire) Read the 148-page research report with TOC on “Smart Lock Market Analysis Report by end-user (residential and others), by geography (APAC, North America, Europe, MEA, and South America), and Segment Forecasts, 2019 – 2023″. The market is driven by the integration of HMI technologies in smart locks. In addition, the integration of advanced technologies in smart locks is anticipated to further boost the g...

Buoyed by boosting export to the European markets, ceramic items of Bangladesh registered 127 percent growth

Buoyed by boosting export to the European markets, ceramic items of Bangladesh registered 127 percent growth in foreign currency earning. Top buyers of European Union (EU) and other countries have started to move to Bangladesh for ceramic items that pushed export earnings of the sectors to a healthy growth of $ 5.65 crore in the first eight months of the current fiscal, according to statistics of Export Promotion Bureau (EPB). Talking to BSS, Bangladesh Ceramic Manufacturers and Exporters Association (BCMEA) General Secretary Irfan Uddin said China is leading the global ceramic market, especially in the EU markets, but Bangladesh is now expanding its stake. “China used to export ceramic items paying 12 percent duty which has been hiked recently that made Chinese ceramic costlier and has paved the way for Bangladeshis ceramic,” he added. Referring to Bangladesh’s duty free access to EU market, Irfan Uddin also director of FARR Ceramics said: “If we grab the opportunity, it will be a big boost for our industry.” Industry insiders said different factories are running operation in full- swing for getting work orders from foreign buyers and most of the companies have received work or...

Tesla slumps 6% on report of ‘hardcore’ cost-cutting plan

Tesla (TSLA -6.2%) tumbles to fresh two-year lows after reports CEO Elon Musk emailed employees to alert that he and CFO Zach Kirkhorn would scrutinize all expenses as part of “hardcore” cost cutting efforts. Musk also said TSLA’s $2.2B cash reserve “is a lot of money, but actually only gives us about 10 months at the first quarter burn rate to achieve breakeven,” according to a report from Electrek. Musk reportedly said that very small efficiency improvements, such as “better packing density or rearranging process flow to a fewer forklift moves,” can have a great impact if everyone works on it. Self-Tapping Screw, drywall screw, Drywall Screw – ChangLan Fastener,https://www.changlanfastener.com/

Original content available for non-commercial use under a Creative Commons license, except where noted. The Florida

Original content available for non-commercial use under a Creative Commons license, except where noted. The Florida Times-Union ~ 1 Independent Drive, Suite 200, Jacksonville, FL 32202 ~ Privacy Settings ~ Cookie Policy ~ Privacy Policy ~ Terms Of Service Wet Tissue Machine, Wet Wipes Machine, Lens Wipes Machine – Ruirun,http://www.wzruirun.com/

SICK launches sensors that ‘clean up signal response in six axes’

SICK has launched its first dynamic 6-axis inclination sensors – the TMS88 D and TMM88 D. It says the new sensors “achieve unrivalled measurement precision and rapid response times”. The company adds that the sensors will “aid the real-time safe and efficient operation of outdoor vehicles and machinery, such as mobile cranes, construction and agricultural machinery, or municipal vehicles”. The SICK TMS88 Dynamic and TMM88 Dynamic inclination sensors use inbuilt gyroscope compensation and an intelligent “sensor fusion” algorithm to clean up signal interference caused by sideways slews, shocks and vibrations. Faster and more accurate measurements, for example of tilts, levels, sloping positions or angles, are therefore provided to support critical, real-time dynamic response of vehicle control systems. At the heart of both sensors is an Inertial Measurement Unit (IMU) consisting of an acceleration sensor and a gyroscope, using MEMS technology to each measure in 360°, x, y and z directions. Proven over 100s of hours of testing with customers in tough conditions, the sensor’s groundbreaking intelligent fusion algorithm then processes the measurements to differentiate between true i...

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